Parkinson’s disease

GLP-1 receptor agonists for Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is a progressive disorder characterised by both motor and non‐motor problems. Glucagon‐like peptide‐1 (GLP‐1) receptor agonists, licensed for treatment of type 2 diabetes, work by stimulating GLP‐1 receptors in the pancreas, which triggers the release of insulin. GLP‐1 receptors have been found in the brain. Insulin signalling in the brain […]

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Cognitive training interventions for dementia and mild cognitive impairment in Parkinson’s disease

Abstract Plain language summary Cognitive training interventions for dementia and mild cognitive impairment in Parkinson’s disease Review question We wanted to know whether cognitive training interventions are effective in improving cognition (thinking) in people with Parkinson’s disease dementia or mild cognitive impairment. Background Approximately 60% to 80% of people with Parkinson’s disease (PD) develop some […]

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Virtual reality for rehabilitation in Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is a neurodegenerative disorder that is best managed by a combination of medication and regular physiotherapy. In this context, virtual reality (VR) technology is proposed as a new rehabilitation tool with a possible added value over traditional physiotherapy approaches. It potentially optimises motor learning in a safe environment, and by […]

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Transcranial direct current stimulation (tDCS) for idiopathic Parkinson’s disease

Abstract Background Idiopathic Parkinson’s disease (IPD) is a neurodegenerative disorder, with the severity of the disability usually increasing with disease duration. IPD affects patients’ health-related quality of life, disability, and impairment. Current rehabilitation approaches have limited effectiveness in improving outcomes in patients with IPD, but a possible adjunct to rehabilitation might be non-invasive brain stimulation […]

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Interventions for fatigue in Parkinson’s disease

Abstract Background Factors contributing to subjective fatigue in people with idiopathic Parkinson’s disease (PD) are not well known. This makes it difficult to manage fatigue effectively in PD. Objectives To evaluate the effects of pharmacological and non-pharmacological interventions, compared to an inactive control intervention, on subjective fatigue in people with PD. Search methods We searched […]

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Treadmill training for patients with Parkinson’s disease

Abstract Background Treadmill training is used in rehabilitation and is described as improving gait parameters of patients with Parkinson’s disease. Objectives To assess the effectiveness of treadmill training in improving the gait of patients with Parkinson’s disease and the acceptability and safety of this type of therapy. Search methods We searched the Cochrane Movement Disorders […]

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Creatine for Parkinson’s disease

Abstract Background Parkinson’s disease is one of the most common neurodegenerative disorders and mitochondrial dysfunction plays an important role in its pathogenesis. Creatine is effective in improving mitochondrial function. It may therefore be useful for slowing the progression of Parkinson’s disease. Objectives To assess the efficacy and safety of creatine used alone or as an […]

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Physiotherapy for Parkinson’s disease: a comparison of techniques

Abstract Background Despite medical therapies and surgical interventions for Parkinson’s disease (PD), patients develop progressive disability. The role of physiotherapy is to maximise functional ability and minimise secondary complications through movement rehabilitation within a context of education and support for the whole person. The overall aim is to optimise independence, safety and wellbeing, thereby enhancing […]

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Physiotherapy versus placebo or no intervention in Parkinson’s disease

Abstract Background Despite medical therapies and surgical interventions for Parkinson’s disease (PD), patients develop progressive disability. Physiotherapy aims to maximise functional ability and minimise secondary complications through movement rehabilitation within a context of education and support for the whole person. The overall aim is to optimise independence, safety, and well-being, thereby enhancing quality of life. […]

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Comparison of speech and language therapy techniques for speech problems in Parkinson’s disease

Abstract Background Patients with Parkinson’s disease commonly suffer from speech and voice difficulties such as impaired articulation and reduced loudness. Speech and language therapy (SLT) aims to improve the intelligibility of speech with behavioural treatment techniques or instrumental aids. Objectives To compare the efficacy and effectiveness of novel SLT techniques versus a standard SLT approach […]

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