Neuro child

Antiepileptic drugs for the treatment of infants with severe myoclonic epilepsy

Abstract Background This is an updated version of the original Cochrane review published in 2015, Issue 10. Severe myoclonic epilepsy in infants (SMEI), also known as Dravet syndrome, is a rare, refractory form of epilepsy, for which stiripentol (STP) has been recently licensed as add-on therapy. Objectives To evaluate the efficacy and tolerability of STP […]

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Family therapy for autism spectrum disorders

Abstract Background Autism spectrum disorders (ASDs) are characterised by impairments in communication and reciprocal social interaction. These impairments can impact on relationships with family members, augment stress and frustration, and contribute to behaviours that can be described as challenging. Family members of individuals with ASD can experience high rates of carer stress and burden, and […]

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Repeated lumbar or ventricular punctures in newborns with intraventricular haemorrhage

Abstract Background Although in recent years the percentage of preterm infants who suffer intraventricularhaemorrhage (IVH) has reduced, posthaemorrhagic hydrocephalus (PHH) remains a serious problem with a high rate of cerebral palsy and no evidence‐based treatment. Survivors often have to undergo ventriculoperitoneal shunt (VPS) surgery, which makes the child permanently dependent on a valve and catheter […]

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Iodine-131-meta-iodobenzylguanidine therapy for patients with newly diagnosed high-risk neuroblastoma

Abstract Background Patients with newly diagnosed high-risk (HR) neuroblastoma (NBL) still have a poor outcome, despite multi-modality intensive therapy. This poor outcome necessitates the search for new therapies, such as treatment with 131I-meta-iodobenzylguanidine (131I-MIBG). Objectives To assess the efficacy and adverse effects of 131I-MIBG therapy in patients with newly diagnosed HR NBL. Search methods We […]

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Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD)

Abstract Background The rising prevalence of autism spectrum disorder (ASD) has increased the need for evidence-based treatments to lessen the impact of symptoms. Presently, no therapies are available to effectively treat individuals with all of the symptoms of this disorder. It has been suggested that hyperbaric oxygen therapy may alleviate the biochemical dysfunction and clinical […]

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Oral appliances and functional orthopaedic appliances for obstructive sleep apnoea in children

Abstract Background Apnoea is a breathing disorder marked by the absence of airflow at the nose or mouth. In children, risk factors include adenotonsillar hypertrophy, obesity, neuromuscular disorders and craniofacial anomalies. The most common treatment for obstructive sleep apnoea syndrome (OSAS) in childhood is adeno-tonsillectomy. This approach is limited by its surgical risks, mostly in […]

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Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders

Abstract Background About 5% of school children have a specific learning disorder, defined as unexpected failure to acquire adequate abilities in reading, writing or mathematics that is not a result of reduced intellectual ability, inadequate teaching or social deprivation. Of these events, 80% are reading disorders. Polyunsaturated fatty acids (PUFAs), in particular, omega‐3 and omega‐6fatty […]

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Intracystic bleomycin for cystic craniopharyngiomas in children

Abstract Background Craniopharyngiomas are the most common benign histological tumours to involve the hypothalamo-pituitary region in childhood. Cystic craniopharyngiomas account for more than 90% of the tumours. The optimal treatment of cystic craniopharyngioma remains controversial. Radical resection is the treatment of choice in patients with favourable tumour localisation. When the tumour localisation is unfavourable, a […]

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Technological aids for the rehabilitation of memory and executive functioning in children and adolescents with acquired brain injury

Abstract Background The use of technology in healthcare settings is on the increase and may represent a cost-effective means of delivering rehabilitation. Reductions in treatment time, and delivery in the home, are also thought to be benefits of this approach. Children and adolescents with brain injury often experience deficits in memory and executive functioning that […]

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Radiotherapy for diffuse brainstem glioma in children and young adults

Abstract Background Diffuse brainstem glioma is a devastating disease with very poor prognosis. The most commonly used radiological treatment is conventional fractionated radiation. So far, there is no meta-analysis or systematic review available that assesses the benefits or harms of radiation in people with diffuse brainstem glioma. Objectives To assess the effects of conventional fractionated […]

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