Neuromuscular disorders

Physical training for McArdle disease

Abstract Background McArdle disease is a rare metabolic myopathy caused by a complete absence of the enzyme muscle glycogen phosphorylase. Affected people experience symptoms of fatigue and cramping within minutes of exercise and are at risk for acute muscle injury (rhabdomyolysis) and acute renal failure. If the first few minutes of exercise are paced, a […]

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Physical therapy for Bell´s palsy (idiopathic facial paralysis)

Abstract Background Bell’s palsy (idiopathic facial paralysis) is commonly treated by various physical therapy strategies and devices, but there are many questions about their efficacy. Objectives To evaluate physical therapies for Bell’s palsy (idiopathic facial palsy). Search methods We searched the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials (The […]

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Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults

Abstract Background Valproic acid and its sodium salt (sodium valproate) are antiepileptic drugs that are sometimes used to treat chronic neuropathic pain and fibromyalgia, although they are not licensed for this use. Objectives To evaluate the analgesic efficacy and adverse effects of valproic acid and sodium valproate in the management of chronic neuropathic pain and […]

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Neurosurgical interventions for the treatment of classical trigeminal neuralgia

Abstract Background Surgical interventions are used for trigeminal neuralgia when drug treatment fails. Surgical treatments divide into two main categories, ablative (destructive) or non-ablative. These treatments can be done at three different sites: peripherally, at the Gasserian ganglion level, and within the posterior fossa of the skull. Objectives To assess the efficacy of neurosurgical interventions for […]

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Multidisciplinary care for adults with amyotrophic lateral sclerosis or motor neuron disease

Abstract Background Multidisciplinary care (MDC) is increasingly thought to be an important means of symptomatic and supportive management for motor neuron disease (MND) but the evidence base for its effectiveness is unclear. This is the first update of a review first published in 2009. Objectives To assess the effectiveness of MDC in adults with MND, […]

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Treatment for idiopathic and hereditary neuralgic amyotrophy (brachial neuritis)

Abstract Background Neuralgic amyotrophy (also know as Parsonage-Turner syndrome or brachial plexus neuritis) is a distinct peripheral nervous system disorder characterised by episodes (attacks) of extreme neuropathic pain and rapid multifocal weakness and atrophy in the upper limbs. Neuralgic amyotrophy has both an idiopathic and hereditary form, with similar clinical symptoms but generally an earlier […]

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Treatment for idiopathic and hereditary neuralgic amyotrophy (brachial neuritis)

Abstract Background Neuralgic amyotrophy (also know as Parsonage-Turner syndrome or brachial plexus neuritis) is a distinct peripheral nervous system disorder characterised by episodes (attacks) of extreme neuropathic pain and rapid multifocal weakness and atrophy in the upper limbs. Neuralgic amyotrophy has both an idiopathic and hereditary form, with similar clinical symptoms but generally an earlier […]

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Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis or motor neuron disease

Abstract Background Amyotrophic lateral sclerosis, also known as motor neuron disease, is a fatal neuromuscular disease characterized by progressive muscle weakness resulting in paralysis. It might be treated with ciliary neurotrophic factor. This is an updated review. An updated search was performed in April 2011, but no new studies were found. Objectives The objective of […]

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Immunosuppressive treatment for non-systemic vasculitic neuropathy

Abstract Background Non-systemic vasculitic neuropathy is a rare disabling disease that usually has a subacute onset of progressive or relapsing-remitting sensory or sensorimotor deficits. Asymmetry, pain and weakness are key features. The diagnosis can only be made by exclusion of other causes, the absence of systemic vasculitis or other rheumatic diseases, and the demonstration of […]

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Vaccination for preventing postherpetic neuralgia

Abstract Background Herpes zoster virus vaccine was recommended for the prevention of herpes zoster and its sequelae by the Advisory Committee on Immunization Practices (ACIP) in 2006. To date the efficacy and safety of vaccination for preventing the most common complication of zoster, postherpetic neuralgia, has not been systematically reviewed. Objectives To assess the efficacy and safety of vaccination in preventing postherpetic neuralgia. […]

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