Peripheral nerve diseases

Vitamin B for treating peripheral neuropathy

Abstract Background Vitamin B is frequently used for treating peripheral neuropathy but its efficacy is not clear. Objectives The objective of this review was to assess the effects of vitamin B for treating generalised peripheral neuropathy. Search methods We searched the Cochrane Neuromuscular Disease Group Trials Register (searched August 2005), MEDLINE (January 1966 to September […]

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Treatment for Charcot-Marie-Tooth disease

Abstract Background Charcot-Marie-Tooth disease (CMT) comprises a large variety of different forms of motor and sensory neuropathies. The most frequent are demyelinating forms (CMT1) and axonal forms (CMT2). The molecular basis of several CMT forms has been clarified during the last 15 years. Since muscle wasting and sensory disturbance are the main features of these […]

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Surgical treatment options for carpal tunnel syndrome

Abstract Background Carpal tunnel syndrome is a common disorder for which several surgical treatment options are available. Objectives To compare the efficacy of the various surgical techniques in relieving symptoms and promoting return to work or activities of daily living and to compare the occurrence of side-effects and complications in patients suffering from carpal tunnel […]

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Aldose reductase inhibitors for the treatment of diabetic polyneuropathy

Abstract Background Polyneuropathy, a common complication of diabetes mellitus, causes pain and sensory and motor deficits in the limbs, and is also an important independent predictor of foot ulceration. Inhibiting the metabolism of glucose by the polyol pathway using aldose reductase inhibitors is a potential mechanism to slow or reverse the neuropathy’s progression. Objectives To […]

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Local corticosteroid injection for carpal tunnel syndrome

Abstract Background Carpal tunnel syndrome is a clinical syndrome manifested by signs and symptoms of irritation of the median nerve at the carpal tunnel in the wrist. Local corticosteroid injection for carpal tunnel syndrome has been studied but its effectiveness is unknown. Objectives To evaluate the effectiveness of local corticosteroid injection for carpal tunnel syndrome […]

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Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome

Abstract Background Non-surgical treatment for carpal tunnel syndrome is frequently offered to those with mild to moderate symptoms. The effectiveness and duration of benefit from non-surgical treatment for carpal tunnel syndrome remain unknown. Objectives To evaluate the effectiveness of non-surgical treatment (other than steroid injection) for carpal tunnel syndrome versus a placebo or other non-surgical, […]

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