Ischaemic

Iron chelators for acute stroke

Abstract Background Stroke is the second leading cause of death and a major cause of morbidity worldwide. Retrospective clinical and animal studies have demonstrated neuroprotective effects of iron chelators in people with haemorrhagic or ischaemic stroke. This is the first update of the original Cochrane Review published in 2012. Objectives To evaluate the effectiveness and safety of iron‐chelating drugs […]

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Citicoline for treating people with acute ischemic stroke

Abstract Background Stroke is one of the leading causes of long‐lasting disability and mortality and its global burden has increased in the past two decades. Several therapies have been proposed for the recovery from, and treatment of, ischemic stroke. One of them is citicoline. This review assessed the benefits and harms of citicoline for treating […]

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Cerebrolysin for acute ischaemic stroke

Abstract Background Cerebrolysin is a mixture of low‐molecular‐weight peptides and amino acids derived from porcine brain that has potential neuroprotective properties. It is widely used in the treatment of acute ischaemic stroke in Russia, Eastern Europe, China, and other Asian and post‐Soviet countries. This is an update of a review first published in 2010 and […]

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Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack

Abstract Background Peroxisome proliferator‐activated receptor gamma (PPAR‐γ) agonists are insulin‐sensitising drugs used for the treatment of insulin resistance. In addition to lowering glucose in diabetes, these drugs may also protect against hyperlipidaemia and arteriosclerosis, which are risk factors for stroke. This is an update of a review first published in January 2014 and subsequently updated […]

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Calcium antagonists for acute ischemic stroke

Abstract Background The sudden loss of blood supply in ischemic stroke is associated with an increase of calcium ions within neurons. Inhibiting this increase could protect neurons and might reduce neurological impairment, disability, and handicap after stroke. Objectives To assess the effects of calcium antagonists for reducing the risk of death or dependency after acute […]

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Remote ischaemic conditioning for preventing and treating ischaemic stroke

Abstract Background Remote ischaemic conditioning (RIC) has been developed as a neuroprotective strategy to prevent and treat ischaemic stroke. It usually involves restricting blood flow to limbs and then releasing the ischaemic blood to promote a neuroprotective effect. Preclinical studies have suggested that RIC may have beneficial effects in ischaemic stroke patients and those at […]

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Antibiotic therapy for preventing infections in patients with acute stroke

Abstract Background Stroke is the main cause of disability in high-income countries and ranks second as a cause of death worldwide. Infections occur frequently after stroke and may adversely affect outcome. Preventive antibiotic therapy in the acute phase of stroke may reduce the incidence of infections and improve outcome. In the previous version of this […]

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Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke

Abstract Background Nitric oxide (NO) has multiple effects that may be beneficial in acute stroke, including lowering blood pressure, and promoting reperfusion and cytoprotection. Some forms of nitric oxide synthase inhibition (NOS-I) may also be beneficial. However, high concentrations of NO are likely to be toxic to brain tissue. This is an update of a […]

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Low-molecular-weight heparins or heparinoids versus standard unfractionated heparin for acute ischaemic stroke

Abstract Background Low-molecular-weight heparins (LMWHs) and heparinoids are anticoagulants that may have more powerful antithrombotic effects than standard unfractionated heparin (UFH) but a lower risk of bleeding complications. This is an update of the original Cochrane Review of these agents, first published in 2001 and last updated in 2008. Objectives To determine whether antithrombotic therapy […]

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Puerarin for acute ischaemic stroke

Abstract Background Puerarin, a form of herbal medicine, is widely used in the treatment of ischaemic stroke in China. Objectives To assess the effects of puerarin in people with ischaemic stroke. Search methods We searched the Cochrane Stroke Group Trials Register and the Chinese Stroke Trials Register (last searched August 2015). In addition, we searched […]

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