Enhancement of normal cognitive functions

L-carnitine for cognitive enhancement in people without cognitive impairment

Abstract Background Safe interventions to enhance cognitive function in cognitively healthy people would be very valuable for several reasons, including a better quality of life and professional success. While L-carnitine has been reported to enhance cognitive function in some conditions, its efficacy is disputed. The evidence of its efficacy for cognitively healthy people has not […]

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Aerobic exercise to improve cognitive function in older people without known cognitive impairment

Abstract Background There is increasing evidence that physical activity supports healthy ageing. Exercise is helpful for cardiovascular, respiratory and musculoskeletal systems, among others. Aerobic activity, in particular, improves cardiovascular fitness and, based on recently reported findings, may also have beneficial effects on cognition among older people. Objectives To assess the effect of aerobic physical activity, […]

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Cognition-based interventions for healthy older people and people with mild cognitive impairment

Abstract Background Evidence from some, but not all non-randomised studies suggest the possibility that cognitive training may influence cognitive functioning in older people. Due to the differences among cognitive training interventions reported in the literature, giving a general overview of the current literature remains difficult. Objectives To systematically review the literature and summarize the effect […]

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Ginseng for cognition

Abstract Background Ginseng is a herbal medicine in widespread use throughout the world. Its effect on the brain and nervous system has been investigated. It has been suggested, on the basis of both laboratory and clinical studies, that it may have beneficial effects on cognitive performance. Objectives To evaluate the efficacy and adverse effects of […]

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Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people

Abstract Background Folate deficiency can result in congenital neural tube defects and megaloblastic anaemia. Low folate levels may be due to insufficient dietary intake or inefficient absorption, but impaired metabolic utilization also occurs. Because B12 deficiency can produce a similar anaemia to folate deficiency, there is a risk that folate supplementation can delay the diagnosis […]

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Hormone replacement therapy for cognitive function in postmenopausal women

Abstract Background As estrogens have been found in animal models to be associated with the maintenance and protection of brain structures, it is biologically plausible that maintaining high levels of estrogens in postmenopausal women by medication could be protective against cognitive decline. Objectives To investigate the effect of ERT (estrogens only) or HRT (estrogens combined […]

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Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly people

Abstract Background In view of the theoretical possibility of beneficial effects of DHEA retarding age-associated deterioration in cognitive function, we have reviewed studies in this area. Objectives To establish whether administration of DHEA improves cognitive function or quality of life or reduces the rate of decline of cognitive function in normal older adults. Search methods […]

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Vitamin B6 for cognition

Abstract Background Micronutrient status can affect cognitive function at all ages. Vitamin deficiencies could influence memory function and might contribute to age-associated cognitive impairment and dementia. Vitamin B6, comprising three chemically distinct compounds, pyridoxal, pyridoxamine, and pyridoxine, is involved in the regulation of mental function and mood. Vitamin B6 is also an essential homocysteine re-methylation […]

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Vitamin B12 for cognition

Abstract Background An association between neuropsychiatric disorders and vitamin B12 deficiency has been recognized since 1849 when pernicious anaemia was first described. It has been suggested that deficiency of vitamin B12 might contribute to age-associated cognitive impairment. Low serum vitamin B12 concentrations are found in more than 10% of older people. A high prevalence of […]

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  • The review abstracts published on this site are the property of John Wiley & Sons, Ltd., and of the Cochrane Review Groups that have produced the reviews.
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