Non pharmacological treatment

Dietary interventions for multiple sclerosis‐related outcomes

Abstract Background Multiple sclerosis (MS) is a common demyelinating disease of the central nervous system. Although the exact pathogenesis remains unknown, the leading theory is that it results from immune system dysregulation. Approved disease‐modifying therapy appears to modulate the immune system to improve MS‐related outcomes. There is substantial interest in the ability of dietary interventions […]

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Interventions for preventing falls in people with multiple sclerosis

Abstract Background Multiple sclerosis (MS) is one of the most prevalent diseases of the central nervous system with recent prevalence estimates indicating that MS directly affects 2.3 million people worldwide. Fall rates of 56% have been reported among people with MS in a recent meta‐analysis. Clinical guidelines do not outline an evidence‐based approach to falls […]

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Palliative care interventions for people with multiple sclerosis

Abstract Background People with multiple sclerosis (MS) have complex symptoms and different types of needs. These demands include how to manage the burden of physical disability as well as how to organise daily life, restructure social roles in the family and at work, preserve personal identity and community roles, keep self‐sufficiency in personal care, and […]

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Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis patients

Abstract Background Multiple sclerosis (MS) is a leading cause of neurological disability in young adults. The most widely accepted hypothesis regarding its pathogenesis is that it is an immune‐mediated disease. It has been hypothesised that intraluminal defects, compression, or hypoplasia in the internal jugular or azygos veins may be important factors in the pathogenesis of […]

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Rehabilitation for people with multiple sclerosis: an overview of Cochrane Reviews

Abstract Background Multiple sclerosis (MS) is a major cause of chronic, neurological disability, with a significant long‐term disability burden, often requiring comprehensive rehabilitation. Objectives To systematically evaluate evidence from published Cochrane Reviews of clinical trials to summarise the evidence regarding the effectiveness and safety of rehabilitation interventions for people with MS (pwMS), to improve patient […]

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Non-pharmacological interventions for chronic pain in multiple sclerosis

Abstract Background Chronic pain is common and significantly impacts on the lives of persons with multiple sclerosis (pwMS). Various types ofnon‐pharmacological interventions are widely used, both in hospital and ambulatory/mobility settings to improve pain control in pwMS, but the effectiveness and safety of many non‐pharmacologicalmodalities is still unknown. Objectives This review aimed to investigate the […]

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Respiratory muscle training for multiple sclerosis

Abstract Background Multiple sclerosis (MS) is a chronic disease of the central nervous system, affecting approximately 2.5 million people worldwide. People with MS may experience limitations in muscular strength and endurance – including the respiratory muscles, affecting functional performance and exercise capacity. Respiratory muscle weakness can also lead to diminished performance on coughing, which may […]

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Polyunsaturated fatty acid supplementation for drug-resistant epilepsy

Abstract Background An estimated 1% to 3% of all individuals will receive a diagnosis of epilepsy during their lives, which corresponds to approximately 50 million affected people worldwide. The real prevalence is possibly higher because epilepsy is underreported in developing countries. Although most will achieve adequate control of their disease though the use of medication, […]

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Memory Rehabilitation for people with multiple sclerosis

Abstract Background This is an update of the Cochrane review ‘Memory rehabilitation for people with multiple sclerosis’ (first published in the Cochrane Library 14 March 2012, Issue 3). Impairments in cognitive function, particularly memory, are common in people with multiple sclerosis (MS) and can potentially affect their ability to complete functional activities. There is evidence […]

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Exercise therapy for fatigue in multiple sclerosis

Abstract Background Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system affecting an estimated 1.3 million people worldwide. It is characterised by a variety of disabling symptoms of which excessive fatigue is the most frequent. Fatigue is often reported as the most invalidating symptom in people with MS. Various mechanisms directly and […]

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