Acute treatment

Surgical and radiological interventions for treating symptomatic extracranial cervical artery dissection

Abstract Background Cervical artery dissection (CeAD) is a pathological bleed or tear, or both, in the wall of the carotid or vertebral arteries as they course through the neck, and is a leading cause of stroke in young people. Objectives To assess the effectiveness of surgical and radiological interventions versus best medical treatment alone for […]

Share

Iron chelators for acute stroke

Abstract Background Stroke is the second leading cause of death and a major cause of morbidity worldwide. Retrospective clinical and animal studies have demonstrated neuroprotective effects of iron chelators in people with haemorrhagic or ischaemic stroke. This is the first update of the original Cochrane Review published in 2012. Objectives To evaluate the effectiveness and safety of iron‐chelating drugs […]

Share

Citicoline for treating people with acute ischemic stroke

Abstract Background Stroke is one of the leading causes of long‐lasting disability and mortality and its global burden has increased in the past two decades. Several therapies have been proposed for the recovery from, and treatment of, ischemic stroke. One of them is citicoline. This review assessed the benefits and harms of citicoline for treating […]

Share

Cerebrolysin for acute ischaemic stroke

Abstract Background Cerebrolysin is a mixture of low‐molecular‐weight peptides and amino acids derived from porcine brain that has potential neuroprotective properties. It is widely used in the treatment of acute ischaemic stroke in Russia, Eastern Europe, China, and other Asian and post‐Soviet countries. This is an update of a review first published in 2010 and […]

Share

Organised inpatient (stroke unit) care for stroke: network meta‐analysis

Abstract Background Organised inpatient (stroke unit) care is provided by multi‐disciplinary teams that manage stroke patients. This can been provided in a ward dedicated to stroke patients (stroke ward), with a peripatetic stroke team (mobile stroke team), or within a generic disability service (mixed rehabilitation ward). Team members aim to provide co‐ordinated multi‐disciplinary care using […]

Share

Marine‐derived n‐3 fatty acids therapy for stroke

Abstract Background Currently, with stroke burden increasing, there is a need to explore therapeutic options that ameliorate the acute insult. There is substantial evidence of a neuroprotective effect of marine‐derived n‐3 polyunsaturated fatty acids (PUFAs) in experimental stroke, leading to a better functional outcome. Objectives To assess the effects of administration of marine‐derived n‐3 PUFAs […]

Share

Prehospital stroke scales as screening tools for early identification of stroke and transient ischemic attack

Abstract Background Rapid and accurate detection of stroke by paramedics or other emergency clinicians at the time of first contact is crucial for timely initiation of appropriate treatment. Several stroke recognition scales have been developed to support the initial triage. However, their accuracy remains uncertain and there is no agreement which of the scales perform […]

Share

Calcium antagonists for acute ischemic stroke

Abstract Background The sudden loss of blood supply in ischemic stroke is associated with an increase of calcium ions within neurons. Inhibiting this increase could protect neurons and might reduce neurological impairment, disability, and handicap after stroke. Objectives To assess the effects of calcium antagonists for reducing the risk of death or dependency after acute […]

Share

Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke

Abstract Background Most ischaemic strokes are caused by blockage of a cerebral artery by a thrombus. Intravenous administration of recombinant tissue plasminogen activator given within 4.5 hours is now standardtreatment for this condition. Percutaneous vascular interventionsuse an intra‐arterial, mechanical approach for thrombus disruption or removal (thrombectomy). Recent randomised trials indicate thatpercutaneous vascular interventions are superior […]

Share

Antibiotic therapy for preventing infections in patients with acute stroke

Abstract Background Stroke is the main cause of disability in high-income countries and ranks second as a cause of death worldwide. Infections occur frequently after stroke and may adversely affect outcome. Preventive antibiotic therapy in the acute phase of stroke may reduce the incidence of infections and improve outcome. In the previous version of this […]

Share
  • The review abstracts published on this site are the property of John Wiley & Sons, Ltd., and of the Cochrane Review Groups that have produced the reviews.
Share
Share