Motor neuron diseases

Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease

Abstract Background Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is terminal, progressive neurological condition for which there are no curative treatments. Among people with ALS/MND, fatigue is a common and debilitating symptom, which is characterised by reversible motor weakness and whole-body tiredness that is only partially relieved by rest. The effectiveness […]

Share

Invasive versus non-invasive ventilation for acute respiratory failure in neuromuscular disease and chest wall disorders

Abstract Background Acute respiratory failure is a common life-threatening complication of acute onset neuromuscular diseases, and may exacerbate chronic hypoventilation in patients with neuromuscular disease or chest wall disorders. Standard management includes oxygen supplementation, physiotherapy, cough assistance, and, whenever needed, antibiotics and intermittent positive pressure ventilation. Non-invasive mechanical ventilation (NIV) via nasal, buccal or full-face […]

Share

Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease

Abstract Background Motor neuron disease (MND), which is also known as amyotrophic lateral sclerosis (ALS), causes a wide range of symptoms but the evidence base for the effectiveness of the symptomatic treatment therapies is limited. Objectives To summarise the evidence from Cochrane Systematic Reviews of all symptomatic treatments for MND. Methods We searched the Cochrane […]

Share

Gamma aminobutyric acid (GABA) modulators for amyotrophic lateral sclerosis/motor neuron disease

Abstract Background Imbalance of gamma aminobutyric acid (GABA) and related modulators has been implicated as an important factor in the pathogenesis of amyotrophic lateral sclerosis (ALS), which is also known as motor neuron disease (MND). In this context, the role and mechanism of action of gabapentin and baclofen have been extensively investigated, although with conflicting […]

Share

Stretch for the treatment and prevention of contractures

Abstract Background Contractures are a common complication of neurological and non-neurological conditions, and are characterised by a reduction in joint mobility. Stretch is widely used for the treatment and prevention of contractures. However, it is not clear whether stretch is effective. This review is an update of the original 2010 version of this review. Objectives […]

Share

Cell-based therapies for amyotrophic lateral sclerosis/motor neuron disease

Abstract Background Amyotrophic lateral sclerosis (ALS), which is also known as motor neuron disease (MND) is a fatal disease associated with rapidly progressive disability, for which no definitive treatment as yet exists. Current treatment regimens largely focus on relieving symptoms to improve the quality of life of those affected. Based on data from preclinical studies, […]

Share

Pharmacological treatments for fatigue associated with palliative care

Abstract Background This review updates the original review, ‘Pharmacological treatments for fatigue associated with palliative care’ and also incorporates the review ‘Drug therapy for the management of cancer-related fatigue’. In healthy individuals, fatigue is a protective response to physical or mental stress, often relieved by rest. By contrast, in palliative care patients’ fatigue can be […]

Share

Nocturnal mechanical ventilation for chronic hypoventilation in patients with neuromuscular and chest wall disorders

Abstract Background Chronic alveolar hypoventilation is a common complication of many neuromuscular and chest wall disorders. Long-term nocturnal mechanical ventilation is commonly used to treat it. This is a 2014 update of a review first published in 2000 and previously updated in 2007. Objectives To examine the effects on mortality of nocturnal mechanical ventilation in […]

Share

Mechanical insufflation-exsufflation for people with neuromuscular disorders

Abstract Background People with neuromuscular disorders (NMDs) may have weak respiratory (breathing) muscles which makes it difficult for them to effectively cough and clear mucus from the lungs. This places them at risk of recurrent chest infections and chronic lung disease. Mechanical insufflation-exsufflation (MI-E) is one of a number of techniques available to improve cough […]

Share

Passive movements for the treatment and prevention of contractures

Abstract Background Contractures, a common complication following immobility, lead to restricted joint range of motion. Passive movements (PMs) are widely used for the treatment and prevention of contractures; however, it is not clear whether they are effective. Objectives The aim of this review was to determine the effects of PMs on persons with contractures or […]

Share
  • The review abstracts published on this site are the property of John Wiley & Sons, Ltd., and of the Cochrane Review Groups that have produced the reviews.
Share
Share