Antiepileptic Drugs

Clonazepam add‐on therapy for refractory epilepsy in adults and children

Abstract Background Epilepsy affects about 50 million people worldwide, nearly a quarter of whom have drug‐refractory epilepsy. People with drug‐refractory epilepsy have increased risks of premature death, injuries, psychosocial dysfunction, and a reduced quality of life. Objectives To assess the efficacy and tolerability of clonazepam when used as an add‐on therapy foradults and children with […]

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Rufinamide add-on therapy for refractory epilepsy

Abstract Background Epilepsy is a central nervous system disorder (neurological disorder). Epileptic seizures are the result of excessive and abnormal cortical nerve cell electrical activity in the brain. Despite the development of more than 10 new antiepileptic drugs (AEDs) since the early 2000s, approximately a third of people with epilepsy remain resistant to pharmacotherapy, often […]

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Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data

Abstract Background Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current […]

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Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis

Abstract Background Viral encephalitis is characterised by diverse clinical and epidemiological features. Seizures are an important clinical manifestation and are associated with increased mortality and morbidity. Patients may have seizures during the acute illness or they may develop after recovery. There are no recommendations regarding the use of antiepileptic drugs for the primary or secondary […]

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Prophylactic drug management for febrile seizures in children

Abstract Background Febrile seizures occurring in a child older than one month during an episode of fever affect 2% to 4% of children in Great Britain and the United States and recur in 30%. Rapid-acting antiepileptics and antipyretics given during subsequent fever episodes have been used to avoid the adverse effects of continuous antiepileptic drugs. […]

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Treatment of epilepsy for people with Alzheimer’s disease

Abstract Background Any type of seizure can be observed in Alzheimer’s disease (AD). Antiepileptic drugs seem to prevent the recurrence of epileptic seizures in most people with AD. There are pharmacological and non-pharmacological treatments for epilepsy in people with AD. There are no current systematic reviews to evaluate the efficacy and tolerability of the treatment. […]

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Immediate antiepileptic drug treatment, versus placebo, deferred, or no treatment for first unprovoked seizure

Abstract Background There is considerable disagreement about the risk of recurrence following a first unprovoked epileptic seizure. A decision about whether to start antiepileptic drug treatment following a first seizure should be informed by information on the size of any reduction in risk of future seizures, the impact on long-term seizure remission, and the risk […]

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Topiramate monotherapy for juvenile myoclonic epilepsy

Abstract Background Topiramate is a newer broad-spectrum of antiepileptic drug (AED). Some studies have shown the benefits of topiramate monotherapy in the treatment of juvenile myoclonic epilepsy (JME). However, there are no current systematic reviews to determine the efficacy and tolerability of topiramate monotherapy in people with JME. Objectives To determine the efficacy and tolerability […]

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Vigabatrin versus carbamazepine monotherapy for epilepsy

Abstract Background This is an update of a Cochrane review first published in 2012 (Cochrane Database of Systematic Reviews 2012, Issue 1). The efficacy and safety of vigabatrin (VGB) as an add-on therapy for refractory epilepsy have been well established. However, this information needs to be weighed against the risk of development of visual field […]

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Sulthiame add-on therapy for epilepsy

Abstract Background Epilepsy is a common neurological condition characterised by recurrent seizures. Most patients respond to conventional antiepileptic drugs, however, around 30% will continue to experience seizures despite multiple antiepileptic drugs. Sulthiame, also known as sultiame, is a widely used antiepileptic drug in Europe and Israel. We present a summary of the evidence for the […]

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