Brain metastasis

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery

Abstract Background Brain radionecrosis (tissue death caused by radiation) can occur following high‐doseradiotherapy to brain tissue and can have a significant impact on a person’s quality of life (QoL) and function. The underlying pathophysiological mechanism remains unclear for this condition, which makes establishing effective treatments challenging. Objectives To assess the effectiveness of interventions used for […]

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Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases

Abstract Background Historically, whole brain radiation therapy (WBRT) has been the main treatment for brain metastases. Stereotactic radiosurgery (SRS) delivers high-dose focused radiation and is being increasingly utilized to treat brain metastases. The benefit of adding SRS to WBRT is unclear. This is an updated version of the original Cochrane review published in Issue 6, […]

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Surgical resection and whole brain radiation therapy versus whole brain radiation therapy alone for single brain metastases

Abstract Background The treatment of brain metastasis is generally palliative since most patients have uncontrollable systemic cancer. Historically, whole brain radiation therapy (WBRT) has been the treatment of choice, although more recently focused radiation therapy e.g. stereotactic radiosurgery (SRS) has developed a role in selected patients. In certain circumstances, such as single brain metastasis, death […]

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Surgery versus radiosurgery for patients with a solitary brain metastasis from non-small cell lung cancer

Abstract Background Non-small cell lung cancer is one of the leading causes of death in developed countries. Brain metastases are often seen in non-small cell lung cancer patients and although they are frequently multiple, a subset of patients with a solitary brain metastasis is regularly seen. Treatment of solitary brain metastasis has been surgery, when […]

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Cranial irradiation for preventing brain metastases of small cell lung cancer in patients in complete remission

Abstract Background Prophylactic cranial irradiation halves the rate of brain metastases in patients with small cell lung cancer. Individual randomized trials conducted on patients in complete remission were unable to clarify whether this treatment improves survival. Objectives This study aims to test whether prophylactic cranial irradiation prolongs survival of patients with small cell lung cancer […]

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