Aminopyridines for symptomatic treatment in multiple sclerosis
Abstract Background The potassium channel blockers 4-aminopyridine (AP) and 3,4-diaminopyridine (DAP) increase nerve conduction in demyelinated nerve fibers, and have been proposed as a symptomatic therapy for people with multiple sclerosis (MS). Objectives To determine the efficacy and safety of aminopyridines for neurological deficits in adults with MS. Search methods We searched the Cochrane MS […]
Anti-spasticity agents for multiple sclerosis
Abstract Background Spasticity is a common problem in multiple sclerosis (MS) patients causing pain, spasms, loss of function and difficulties in nursing care. A variety of oral and parenteral medications are available. Objectives To assess the absolute and comparative efficacy and tolerability of anti-spasticity agents in MS patients. Search methods We searched the Cochrane MS […]
Intravenous immunoglobulins for multiple sclerosis
Abstract Background Animal experiments suggest that intravenous immunoglobulins can reverse some of the disease process of central nervous system demyelination. Subsequently, clinical trials of intravenous immunoglobulins have been conducted in people with multiple sclerosis (MS). Objectives To identify and summarise the evidence that intravenous immunoglobulins are safe and beneficial for people with MS. Search methods […]
Corticosteroids or ACTH for acute exacerbations in multiple sclerosis
Abstract Background Corticosteroids are commonly used to improve the rate of recovery from acute exacerbation in multiple sclerosis (MS) patients. However, it is unclear just how effective these agents are and which is the best treatment schedule (type of drug, dose, frequency, duration of treatment and route of administration). This review is un update of […]
Pharmacotherapy for Behcet’s syndrome
Abstract Background Behcet’s syndrome is a multisystemic disorder presenting with recurrent oral and genital ulcerations as well as ocular involvement. Treatment of Behcet’s syndrome is symptomatic and empirical. Objectives To determine the effects of available pharmacological interventions in treating the different clinical features of Behcet’s syndrome. Search methods We searched the Cochrane Musculoskeletal Group’s trials […]